The syndrome of macrophage activation is a severe and potentially lethal character that occurs as a complication in the context of different diseases, mainly of autoimmune type. The term macrophage activation syndrome was coined by Hadchouel et al in 1985 and has been used almost exclusively for those cases of hemophagocytosis secondary to rheumatological pathology (mainly rheumatoid arthritis).
Pathogeny etiological Clinical pictureThe clinical picture is characterized by nonspecific symptoms such as fatigue, fever and low weight. Among the complications secondary to pancytopenia, pale mucous membranes, spontaneous bleeding and increased infectious conditions can be observed. Diagnosis
The diagnosis is based mainly on clinical and laboratory findings. Treatment
The treatment is mainly based on the management of the underlying pathology, in addition to the use of corticosteroids, cyclosporins and immunological therapy.
Linfohistiocitosis hemofagocítica
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