Manganese peroxidase enzyme (MNP) EC 1.11.1.13 catalyzes the oxidation reaction of manganese (+2) to manganese (+3) ion using hydrogen peroxide. This enzyme uses the heme group as a cofactor. 2 Mn + H2O2 + 2 H ⇌ {\displaystyle \rightleftharpoons } 2 Mn + 2 H2O
This enzyme is produced by the fungus Phanerochaete chrysosporium in three varieties of approximately 380 amino acids each.
There is an additional promoter variety, Manganese peroxidase 5 (MNP5) Q9URB1, of which only a partial sequence of 20 amino acids has been decoded.
The enzyme is secreted outside the cell and requires two calcium ions and one heme B group (iron-protoporphyrin IX) for each subunit. The product, Mn, acts as a diffusible redox agent and is capable of oxidizing a large variety of lignin compounds.
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