Examples of cell signaling lipids: - LPA : acide lysophosphatidique, - S1P : sphingosine-1-phosphate, PAF: platelet activation factor, - AEA : anandamide.
Lipid signaling refers to all the biochemical processes of cell signaling involving lipids that bind to a target protein, such as a receptor, kinase or phosphatase, which in turn triggers other processes within the body. of the cell according to the lipid messengers. Lipid signaling works differently than other signaling processes, such as monoamine neurotransmission, because lipids can diffuse freely through the cell membrane (osmosis). This implies that lipid messengers can not be stored in vesicles before being released and are therefore synthesized in real time near their target. As a result, many signaling lipids do not circulate freely in solution but are bound to transport proteins in the serum.
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